I'm a huge fan of smartwool clothing, but I would hesitate to recommend it for inexperienced hikers if
it's the only base layer you've got.While wool has superior insulating properties when wet, it doesn't dry easily, as synthetic fabrics do. That can leave you stuck in wet clothes, which isn't ideal no matter what you're wearing.
Consequently, with smartwool layers I like to keep polypro longs in my pack to switch into if needed.
Regarding comfort, I'd say smartwool garments rival cotton (assuming you're not allergic to wool).
My 2c.

Andy